Our Experts Working With Your Experts

Next Generation Molecular Method Development

 

MR DNA scientists have over 20 years of continuous experience (not combined experience) developing new and novel molecular methods. Systematics, microsatellite screening, MHC assays, viral assays, protozoan assays and more. Our team’s goal is to take advantage of each new technology as it arrives and leverage unique properties to develop unique, improved and more cost effective molecular methods and tools.

 

 

 

 

Put MR DNA on your team

 

This initiative is one component of the MR DNA program and constitutes a major NIH effort to broaden access to rapid assay technologies. This program will fund the development and adaptation of biological assays for use in automated high throughput molecular screening (HTS). It is intended that this Initiative promote the development of automated screening projects. High throughput molecular screening (HTS) is the automated, simultaneous testing of thousands of distinct molecular signatures in models of biological mechanisms. Active compounds identified through HTS can provide the starting point in the design of powerful research tools that allow pharmacological probing of basic biological mechanisms, and which can be used to establish the role of a molecular target in a disease process, or, its ability to alter the metabolism or toxicity of a therapeutic. The immense potential of HTS to impact our understanding of biological mechanisms is largely untapped because access to automated screening facilities and large compound libraries is limited in academic, government and non-profit research sectors.

 

Many in vitro biological models are currently used to study biological pathways, the effects of genetic perturbations and to establish a disease association. These can be adapted to high throughput formats for the purpose of screening large collections of biologically active compounds. There are a number of characteristics that make an assay suitable for high throughput approaches. The assay must be robust, reproducible and have a readout that is amenable to automated analysis. In addition, it must be possible to miniaturize the assay, for example; to a 96-well plate (or higher density) format or flow-cytometric approach. Further, the assay protocol should be simple enough for automated handling. A broad range of models share many of these features, including; biochemical assays, cellular models and certain model organisms such as yeast or C. elegans. This initiative will support the development of innovative assays for use in both basic research and in therapeutics development programs, with an emphasis on novelty of assay approach and/or novel targets and mechanisms.

 

 

• Bacterial detection and identification
• MHC characterization
• Genotyping
• cSNP indel assays
• Viral and fungal assays
• Genome comparison
• Target enrichment sequencing
• Systematics
• Microsatellite
• Quantitative and expression assays
• Short Read Long Read
• Highly multiplexed assays
• Bioinformatics development
• Screening and development

 

 

 

At Molecular Research MR DNA, we provide a full spectrum of sequencing and bioinformatics services to meet the diverse needs of modern scientific research. From genomics and transcriptomics to metagenomics, epigenomics, and functional studies, we support a broad array of applications across academic, clinical, agricultural, and industrial fields. Our advanced platforms and expert bioinformatics team deliver high-quality data, ensuring actionable insights for every project. Whether you are conducting whole-genome sequencing, analyzing transcriptome dynamics, or exploring the complexity of microbial communities, we are your trusted partner in discovery.

Our services encompass the latest sequencing technologies and methodologies. For whole-genome sequencing, we offer comprehensive solutions for de novo assembly, variant detection, and comparative genomics. RNA sequencing enables the detailed study of gene expression profiles, alternative splicing, and non-coding RNAs. Metagenomic sequencing uncovers microbial diversity and functional potential within environmental, clinical, or industrial samples. Epigenomic analyses reveal critical regulatory mechanisms through methylation profiling and chromatin accessibility assays. Additionally, our custom assay development capabilities allow us to tailor solutions for unique research questions, including targeted sequencing, rare variant detection, and functional genomics studies.

Bioinformatics lies at the core of our services, enabling robust data analysis and interpretation. Our bioinformatics solutions include genome annotation, differential gene expression analysis, pathway enrichment studies, and functional characterization. For metagenomic and microbiome research, we provide taxonomic profiling, diversity metrics, and pathway analysis for microbial communities. We specialize in integrating multi-omics data to offer comprehensive insights into biological systems. Our team is adept at handling large-scale datasets and applying machine learning techniques to uncover patterns and predict functional outcomes. With our expertise, you gain not only high-quality sequencing data but also the computational tools to translate data into discovery.

With extensive experience across a wide range of research areas, Molecular Research MR DNA is your partner for sequencing and bioinformatics excellence. From human health to agriculture, environmental science, and industrial applications, we provide reliable, efficient, and scalable solutions tailored to your specific needs. Our commitment to quality, innovation, and collaboration ensures that your research is supported at every step, from project design to data delivery. Let us help you achieve your research goals with our state-of-the-art sequencing and bioinformatics expertise.